Following a study project, biomedical experts at Case Western Reserve University have reported that a recent improvement in the development of artificial platelets might help save lives by regulating clots in a timely manner to limit blood loss from major injuries.
The new initiative is focused on the development of next-generation nanoparticles that imitate platelets and aid in the formation of a protein mesh that acts as a natural net to manage blood clots and aid in the prevention of bleeding.
If the invention is shown to be safe and effective in human trials, it will add to the progress made by scientists over a decade-long effort to create and refine what are known as synthetic platelet surrogates (synthetic platelet substitutes).
“The breakthrough is the next stage in artificial platelet technology, and it represents a very significant advancement,” said the principal researcher who was responsible for the innovation.
The invention is intended to function in a number of ways, including the formation of a plug to minimise blood loss following a severe injury and the assistance in the formation of fibrin, which is a protein mesh that seals the plug and stabilises the clot even more.
Researchers at Case Western Reserve University have been working on artificial platelet systems for the past decade, and their findings have been published. The team has been hard at work developing therapeutic technologies that have potential in hemostasis, thrombolysis, and inflammation, among other areas.
The outcomes of the study are documented in an article that was published in the journal Science Translational Medicine in 2012.
According to the researchers, the nanoparticles, which they refer to as ‘platelet-mimicking procoagulant nanoparticles,’ aided in the formation of clots more quickly and the cessation of bleeding in animal trials.
When it comes to the physiological function of platelets, this component of blood aids in the blood-clotting process by rapidly gathering at the site of damage, adhering to the lining of the wounded blood vessel, forming clusters to create a plug, and stimulating the creation of fibrin.